4-Bromo-5-fluorobenzene-1,2-diamine

Name: 4-Bromo-5-fluorobenzene-1,2-diamine
Brand: ChemScene
Availability: InStock
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CAS No. 153505-37-4
Cat. No. CS-0098663
Purity≥95%
MDL No.MFCD08458150

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Bromo-5-fluorobenzene-1,2-diamine|CS-0098663

Structure of 153505-37-4

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Description

4-Bromo-5-fluorobenzene-1,2-diamine features two distinct halogen substituents—bromine and fluorine—positioned ortho to each other on a benzene ring, flanking a diamine moiety. This arrangement enables selective coupling reactions in pharmaceutical synthesis, where the bromine serves as a handle for palladium-catalyzed cross-coupling, while the fluorine enhances electronic effects and metabolic stability. The molecule exhibits favorable solubility in common organic solvents and maintains stability under standard bench conditions, facilitating its use in multi-step synthetic sequences.

Application

4-Bromo-5-fluorobenzene-1,2-diamine serves as a versatile building block for heterocyclic synthesis and transition metal-catalyzed coupling reactions. Its complementary halogenation pattern enables selective functionalization via Pd-catalyzed cross-coupling, while the diamine functionality supports direct incorporation into pharmaceutical scaffolds and ligand design. Bench-stable and readily purified, it facilitates efficient access to complex aromatic systems in medicinal chemistry workflows.

General Information

CAS No. 153505-37-4
Cat. No. CS-0098663
Purity ≥95%
MDL No. MFCD08458150
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆BrFN₂
Molecular Weight 205.03
Synonym(s) 4-Bromo-5-fluorophenylene-1,2-diamine, 4-Bromo-1,2-diamino-5-fluorobenzene
SMILES NC1=CC(F)=C(Br)C=C1N

Computational Chemistry Data

TPSA 52.04
LogP 1.7526
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Bromo-5-fluorobenzene-1,2-diamine

CAS No. 153505-37-4

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