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CS-W001157 4
Total: USD 88.00

tert-butyl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate Rosuvastatin Impurity

  • CAS No. 154026-94-5

  • Cat. No. CS-0165342
  • Purity95+%
  • MDL No.MFCD08706402

*For research and further manufacturing use only, not for direct human use.

tert-butyl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate  Rosuvastatin Impurity|CS-0165342

Structure of 154026-94-5

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General Information

  • CAS No. 154026-94-5
  • Cat. No. CS-0165342
  • Purity 95+%
  • MDL No. MFCD08706402
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₃ClO₄
  • Molecular Weight 278.77
  • Synonym(s) tert-butyl [(4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate
  • SMILES O=C(OC(C)(C)C)C[C@@H]1OC(C)(C)O[C@H](CCl)C1

Synthesis

  • Route1
    • null|null
      391218-18-1
    • null|null
      75-65-0
    • ~79%
    • In-stock
      tert-butyl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate  Rosuvastatin Impurity|CS-0165342
      154026-94-5

    References

    • DSM IP ASSESTS B.V. Patent: WO2003/106447 A1, 2003 ; Location in patent: Page 4 ;
  • Route2
    • null|null
      77-76-9
    • (3R,5S)-tert-butyl 6-chloro-3,5-dihydroxyhexanoate  Rosuvastatin Impurity|CS-0165341
      154026-93-4
    • ~10%
    • In-stock
      tert-butyl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate  Rosuvastatin Impurity|CS-0165342
      154026-94-5

    References

    • Wolberg, Michael; Hummel, Werner; Mueller, Michael Chemistry - A European Journal, 2001 , vol. 7, # 21 p. 4562 - 4571
  • Route3
    • null|null
      77-76-9
    • null|null
      406680-96-4
    • ~65%
    • In-stock
      tert-butyl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate  Rosuvastatin Impurity|CS-0165342
      154026-94-5

    References

    • Bode, Silke E.; Muller, Michael; Wolberg, Michael Organic Letters, 2002 , vol. 4, # 4 p. 619 - 621

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.76
  • LogP   2.8672
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

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