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Structure of 1548-61-4
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4-Nitro-2-(trifluoromethyl)phenol features a para-nitro group and a sterically hindered trifluoromethyl substituent on the phenolic ring, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables efficient coupling in C–H functionalization and facilitates access to high-performance agrochemical and pharmaceutical intermediates under standard conditions.
4-Nitro-2-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via electrophilic substitution and coupling reactions. The nitro group facilitates subsequent reductions and cyclizations, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity. Its bench-stable crystalline form allows for straightforward handling and purification, making it well-suited for multi-step synthetic sequences in industrial R&D workflows.
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GHS Pictogram :
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GHS No : GHS05,GHS07,GHS09
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Signal Word : Danger
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H317-H318-H410
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Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501
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Lot numbers can be found on the outside label of a product: