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CS-W001157 4
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1-Bromo-2-(bromomethyl)-3-fluorobenzene

  • CAS No. 1548-81-8

  • Cat. No. CS-0695921
  • Molecule weight267.92
  • Purity≥98%
  • MDL No.MFCD10698675

*For research and further manufacturing use only, not for direct human use.

1-Bromo-2-(bromomethyl)-3-fluorobenzene|CS-0695921

Structure of 1548-81-8

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General Information

  • CAS No. 1548-81-8
  • Cat. No. CS-0695921
  • Purity ≥98%
  • MDL No. MFCD10698675
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅Br₂F
  • Molecular Weight 267.92
  • Synonym(s) None
  • SMILES FC1=CC=CC(Br)=C1CBr

Description

1-Bromo-2-(bromomethyl)-3-fluorobenzene features a fluorinated aromatic ring bearing bromo and bromomethyl substituents in ortho relationship, enabling selective cross-coupling and functionalization. This configuration supports efficient palladium-catalyzed transformations under standard conditions, delivering complex aryl architectures with high regiocontrol.

Application

1-Bromo-2-(bromomethyl)-3-fluorobenzene serves as a versatile bifunctional building block for constructing complex aromatic scaffolds. The bromomethyl group enables nucleophilic substitution and Suzuki-Miyaura coupling, while the ortho-bromo and meta-fluoro substituents offer orthogonal reactivity for sequential functionalization. Its bench-stable nature and compatibility with standard cross-coupling conditions make it well-suited for medicinal chemistry and process-scale synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.4831
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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