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CS-W001157 4
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Hydroxy-PEG8-Boc

  • CAS No. 1334177-84-2

  • Cat. No. CS-0110221
  • Molecule weight498.60
  • Purity≥98%
  • MDL No.MFCD11041105

*For research and further manufacturing use only, not for direct human use.

Hydroxy-PEG8-Boc|CS-0110221

Structure of 1334177-84-2

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General Information

  • CAS No. 1334177-84-2
  • Cat. No. CS-0110221
  • Purity ≥98%
  • MDL No. MFCD11041105
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₄₆O₁₁
  • Molecular Weight 498.60
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCOCCOCCO

Description

Hydroxy-PEG8-Boc features a hydroxyl-terminated poly(ethylene glycol) chain of eight ethylene oxide units, protected at the terminal end with a tert-butoxycarbonyl group. This bifunctional architecture enables selective conjugation and controlled release in bioconjugation workflows. The PEG spacer provides enhanced solubility and reduced aggregation, while the Boc protection ensures stability during synthetic manipulations.

Application

Hydroxy-PEG8-Boc serves as a versatile, bench-stable building block for the synthesis of PEGylated compounds and bioconjugates. The Boc-protected hydroxyl group enables orthogonal handling in multistep syntheses, while the PEG8 spacer provides enhanced solubility and reduced aggregation. This reagent facilitates efficient coupling reactions under mild conditions and is compatible with diverse functional groups, making it ideal for constructing drug delivery systems and targeted therapeutics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   120.37
  • LogP   0.8433
  • H_Acceptors   11
  • H_Donors   1
  • Rotatable_Bonds   26

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