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CS-W001157 4
Total: USD 88.00

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate

  • CAS No. 154825-97-5

  • Cat. No. CS-W018999
  • Purity≥98%
  • MDL No.MFCD02683357
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate|CS-W018999

Structure of 154825-97-5

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Description

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate is a bench-stable, moisture-tolerant building block featuring a sterically hindered quaternary carbon center. The para-bromophenyl group imparts enhanced reactivity in palladium-catalyzed cross-coupling processes, while the ester functionality enables straightforward derivatization. This compound integrates efficiently into complex molecular architectures requiring robust aryl-alkyl linkages.

Application

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate serves as a versatile building block for Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl scaffolds. The bromophenyl group exhibits high reactivity under standard palladium catalysis, while the sterically hindered gem-dimethylacetyl moiety provides excellent bench stability and facilitates straightforward purification. Its compatibility with diverse reaction conditions makes it a reliable intermediate in the synthesis of functionalized aromatic compounds and pharmaceutical precursors.

General Information

  • CAS No. 154825-97-5
  • Cat. No. CS-W018999
  • Purity ≥98%
  • MDL No. MFCD02683357
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃BrO₂
  • Molecular Weight 257.12
  • Synonym(s) P-Bromo-Alpha,Alpha-Dimethyl Phenylacetic
  • SMILES BrC1=CC=C(C=C1)C(C(=O)OC)(C)C

Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.8997
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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