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Structure of 251458-15-8
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Methyl 2-(3-bromophenyl)-2-methylpropanoate features a sterically hindered quaternary carbon bearing a brominated phenyl group and an ester functionality. This configuration enables direct coupling in cross-coupling reactions without requiring pre-functionalization, offering streamlined access to complex aryl-substituted building blocks under standard conditions.
Methyl 2-(3-bromophenyl)-2-methylpropanoate serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromoaryl functionality. The sterically hindered α-methylpropanoate group enhances bench stability and facilitates straightforward purification. This compound functions effectively in Suzuki-Miyaura, Stille, and Negishi couplings, providing access to substituted biaryls and complex scaffolds relevant to pharmaceutical and agrochemical research.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: