4,6-Dichloro-5-fluoropyrimidin-2-amine

Name: 4,6-Dichloro-5-fluoropyrimidin-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 15598-33-1
Cat. No. CS-0109987
Purity≥95%
MDL No.MFCD11870221

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4,6-Dichloro-5-fluoropyrimidin-2-amine|CS-0109987

Structure of 15598-33-1

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Description

4,6-Dichloro-5-fluoropyrimidin-2-amine features a highly reactive pyrimidine core with orthogonal halogen substituents enabling selective cross-coupling. The electron-deficient ring facilitates nucleophilic substitution under mild conditions, while the amino group serves as a direct handle for derivatization in medicinal chemistry and agrochemical synthesis.

Application

4,6-Dichloro-5-fluoropyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitors and antiviral agents. Its electrophilic pyrimidine core undergoes facile nucleophilic substitution with amines, thiols, and heterocycles under mild conditions. The dichloro and fluoro substituents provide orthogonal reactivity for sequential functionalization, while the amine group offers a handle for further derivatization. Bench-stable and readily purified by recrystallization, it is well-suited for scale-up and high-throughput synthesis workflows.

General Information

CAS No. 15598-33-1
Cat. No. CS-0109987
Purity ≥95%
MDL No. MFCD11870221
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₂Cl₂FN₃
Molecular Weight 181.98
Synonym(s) 4,6-Dichloro-5-fluoro-pyrimidin-2-ylamine
SMILES NC1=NC(Cl)=C(F)C(Cl)=N1

Computational Chemistry Data

TPSA 51.8
LogP 1.5047
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4,6-Dichloro-5-fluoropyrimidin-2-amine

CAS No. 15598-33-1

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