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CS-W001157 4
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Naphthalene-2-sulfonamide

  • CAS No. 1576-47-2

  • Cat. No. CS-0188831
  • Molecule weight207.25
  • Purity≥98%
  • MDL No.MFCD00051931

*For research and further manufacturing use only, not for direct human use.

Naphthalene-2-sulfonamide|CS-0188831

Structure of 1576-47-2

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General Information

  • CAS No. 1576-47-2
  • Cat. No. CS-0188831
  • Purity ≥98%
  • MDL No. MFCD00051931
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO₂S
  • Molecular Weight 207.25
  • Synonym(s) NSC 31057
  • SMILES O=S(C1=CC=C2C=CC=CC2=C1)(N)=O

Description

Naphthalene-2-sulfonamide delivers a rigid, electron-deficient aromatic core paired with a sulfonamide handle for precise molecular integration. This bench-stable compound features enhanced solubility in polar solvents and serves as a robust scaffold in medicinal chemistry campaigns targeting kinase inhibition and protein-protein interactions.

Application

Naphthalene-2-sulfonamide serves as a robust scaffold for medicinal chemistry and materials science, offering a stable aromatic core with a versatile sulfonamide handle. It functions as a key building block in the synthesis of kinase inhibitors and other bioactive molecules, benefiting from good bench stability, predictable reactivity, and compatibility with standard coupling protocols. Its moderate solubility profile facilitates purification and process optimization in multi-step syntheses.

Synthesis

  • Route1

    References

    • Aime, Silvio; Botta, Mauro; Cravotto, Giancarlo; Frullano, Luca; Giovenzana, Giovanni B.; Crich, Simonetta Geninatti; Palmisano, Giovanni; Sisti, Massimo Helvetica Chimica Acta, 2005 , vol. 88, # 3 p. 588 - 603
  • Route2
    • null|null
      13407-52-8
    • ~92%
    • In-stock
      Naphthalene-2-sulfonamide|CS-0188831
      1576-47-2

    References

    • Firouzabadi, Habib; Adibi, Mina; Ghadami, Mahboobeh Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 142, p. 191 - 220
  • Route3
    • Trimethyl(naphthalen-2-yl)stannane|CS-0541316
      945-77-7
    • ~%
    • In-stock
      Naphthalene-2-sulfonamide|CS-0188831
      1576-47-2

    References

    • Journal of Organic Chemistry, , vol. 58, # 25 p. 7022 - 7028

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   1.4872
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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