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Structure of 93-11-8
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2-Naphthalenesulfonyl chloride was employed as capping reagent for primary amine to convert histamine to a selective histamine H3-receptor antagonist. It was used for pre-column derivatization during the high-performance liquid chromatographic assay of neomycin sulfate.
Naphthalene-2-sulfonyl chloride serves as a robust sulfonating agent for amine functionalization, enabling efficient synthesis of sulfonamide derivatives under mild conditions. Its stability and ease of handling facilitate straightforward purification, while the naphthalene scaffold provides enhanced solubility and orthogonal reactivity in complex molecule assembly. Widely used in medicinal chemistry and agrochemical synthesis, it functions reliably in standard coupling protocols and supports scalable, high-yield transformations.
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GHS Pictogram :
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H315-H411
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Precautionary Statements : P264-P273-P280-P302+P352-P332+P313-P362+P364-P391-P501
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Lot numbers can be found on the outside label of a product: