1-(Difluoromethoxy)-4-methylbenzene

Name: 1-(Difluoromethoxy)-4-methylbenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1583-83-1
Cat. No. CS-0188795
Purity≥98%
MDL No.MFCD00042253

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(Difluoromethoxy)-4-methylbenzene|CS-0188795

Structure of 1583-83-1

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1583-83-1
Cat. No. CS-0188795
Purity ≥98%
MDL No. MFCD00042253
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈F₂O
Molecular Weight 158.15
Synonym(s) α,α-Difluoro-4-methylanisole
SMILES CC1=CC=C(OC(F)F)C=C1

Description

1-(Difluoromethoxy)-4-methylbenzene features a para-substituted aromatic core bearing a difluoromethoxy group and a methyl moiety, delivering enhanced lipophilicity and metabolic stability. This electron-rich scaffold integrates readily into pharmaceutical intermediates and agrochemical frameworks, offering robust performance under standard bench conditions.

Application

1-(Difluoromethoxy)-4-methylbenzene serves as a valuable building block in medicinal chemistry, offering a stable difluoromethoxy group ortho to a methyl substituent. Its bench-stable nature and compatibility with standard cross-coupling reactions enable efficient access to fluorinated aromatic scaffolds. The molecule functions as a versatile intermediate for constructing bioactive compounds, particularly in agrochemical and pharmaceutical research, where the electron-withdrawing difluoromethoxy moiety enhances metabolic stability and modulates lipophilicity.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H227-H315-H319
Precautionary Statements : P210-P264-P280-P302+P352-P362-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 9.23
LogP 2.59642
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Ether

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

1-(Difluoromethoxy)-4-methylbenzene sigma1-(Difluoromethoxy)-4-methylbenzene manufacturer1-(Difluoromethoxy)-4-methylbenzene price1-(Difluoromethoxy)-4-methylbenzene structure1-(Difluoromethoxy)-4-methylbenzene SDSbuy 1-(Difluoromethoxy)-4-methylbenzene1-(Difluoromethoxy)-4-methylbenzene supplier1-(Difluoromethoxy)-4-methylbenzene uses1-(Difluoromethoxy)-4-methylbenzene molecular weightprice of 1-(Difluoromethoxy)-4-methylbenzene1-(Difluoromethoxy)-4-methylbenzene chemical name formula of 1-(Difluoromethoxy)-4-methylbenzene

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1-(Difluoromethoxy)-4-methylbenzene

CAS No. 1583-83-1

Recommended Products