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Structure of 519059-04-2
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1-(Difluoromethoxy)-4-ethynylbenzene features a terminal alkyne group paired with a difluoromethoxy substituent, enabling efficient copper-catalyzed coupling reactions. The electron-withdrawing fluorine atoms enhance the alkyne's reactivity while maintaining stability under standard conditions. This aryl ethynyl motif integrates readily into complex molecular architectures for pharmaceutical and materials applications.
1-(Difluoromethoxy)-4-ethynylbenzene serves as a versatile building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling efficient access to triazole-linked scaffolds. The terminal alkyne functionality exhibits high reactivity under standard click conditions, while the difluoromethoxy group provides enhanced metabolic stability and favorable lipophilicity. This compound demonstrates excellent bench stability, compatibility with common functional groups, and straightforward purification via flash chromatography, making it well-suited for medicinal chemistry and materials synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: