4-Bromo-2-chloro-1-(trifluoromethoxy)benzene

Name: 4-Bromo-2-chloro-1-(trifluoromethoxy)benzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 158579-80-7
Cat. No. CS-0084311
Molecule weightNone
Purity≥98%
MDL No.MFCD10699114

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-chloro-1-(trifluoromethoxy)benzene|CS-0084311

Structure of 158579-80-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 158579-80-7
Cat. No. CS-0084311
Purity ≥98%
MDL No. MFCD10699114
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃BrClF₃O
Molecular Weight None
Synonym(s) 4-Bromo-2-chloro-alpha,alpha,alpha-trifluoroanisole, 4-Bromo-2-chlorophenyl trifluoromethyl ether
SMILES FC(F)(F)OC1=CC=C(Br)C=C1Cl

Description

4-Bromo-2-chloro-1-(trifluoromethoxy)benzene features a trifluoromethoxy group that enhances electron-withdrawal and metabolic stability, while the ortho-bromo and meta-chloro substituents enable selective coupling in cross-coupling reactions. This aryl halide delivers high functional group tolerance and stability under standard conditions, making it ideal for constructing complex heterocycles and pharmaceutical intermediates.

Application

4-Bromo-2-chloro-1-(trifluoromethoxy)benzene serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biaryl scaffolds under palladium-catalyzed conditions. The ortho-chloro and para-bromo substituents offer complementary reactivity for sequential functionalization, while the trifluoromethoxy group provides enhanced metabolic stability and lipophilicity. Bench-stable and readily purified by column chromatography, it functions reliably in Suzuki, Stille, and Negishi couplings, facilitating rapid access to complex heterocyclic architectures common in pharmaceutical discovery.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 9.23
LogP 4.0011
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

158579-80-7 sigma158579-80-7 manufacturer158579-80-7 price158579-80-7 structure158579-80-7 SDSbuy 158579-80-7158579-80-7 supplier158579-80-7 uses158579-80-7 molecular weightprice of 158579-80-7158579-80-7 chemical name formula of 158579-80-7

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Bromo-2-chloro-1-(trifluoromethoxy)benzene

CAS No. 158579-80-7

Recommended Products