Pyrrolo[2,1-f][1,2,4]triazin-4-amine

Name: Pyrrolo[2,1-f][1,2,4]triazin-4-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 159326-68-8
Cat. No. CS-W003471
Purity≥96%
MDL No.MFCD08234647

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Pyrrolo[2,1-f][1,2,4]triazin-4-amine|CS-W003471

Structure of 159326-68-8

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General Information

CAS No. 159326-68-8
Cat. No. CS-W003471
Purity ≥96%
MDL No. MFCD08234647
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆N₄
Molecular Weight 134.14
Synonym(s) None
SMILES N=1C=NN2C=CC=C2C1N

Description

Pyrrolo[1,2-f][1,2,4]triazin-4-amine integrates a fused heterocyclic core with a primary amine handle, enabling direct functionalization in synthetic sequences. This electron-deficient scaffold supports efficient coupling reactions and exhibits favorable solubility in polar solvents, facilitating use in medicinal chemistry campaigns and combinatorial library synthesis.

Application

Pyrrolo[1,2-f][1,2,4]triazin-4-amine serves as a versatile heterocyclic building block for medicinal chemistry and catalytic synthesis. Its fused tricyclic core exhibits enhanced metabolic stability and favorable π-stacking interactions, enabling efficient incorporation into kinase inhibitors and other bioactive scaffolds. The primary amine group facilitates direct derivatization via amidation, alkylation, or coupling reactions, while the electron-deficient triazine ring supports palladium-catalyzed cross-coupling. Bench-stable and readily purified by column chromatography, it functions effectively in both small-molecule discovery and process development workflows.

Synthesis

Route1
- 937046-98-5
- 68-12-2
- ~%
- 939967-94-9
- In-stock
  
  159326-68-8
References
- WO2007/64931 A2, ; Page/Page column 168 ;
Route2
- 159326-67-7
- ~70%
- In-stock
  
  159326-68-8
References
- Patil; Otter; Klein Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 781 - 786
Route3
- In-stock
  
  1003-29-8
- ~%
- In-stock
  
  159326-68-8
References
- Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 781 - 786

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 56.21
LogP 0.3115
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrrole compounds

Key Words

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Pyrrolo[2,1-f][1,2,4]triazin-4-amine

CAS No. 159326-68-8

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