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7-Chloro-1H-1,8-naphthyridin-2-one

  • CAS No. 15944-34-0

  • Cat. No. CS-0210958
  • Molecule weight180.59
  • Purity≥97%
  • MDL No.MFCD17215762

*For research and further manufacturing use only, not for direct human use.

7-Chloro-1H-1,8-naphthyridin-2-one|CS-0210958

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General Information

  • CAS No. 15944-34-0
  • Cat. No. CS-0210958
  • Purity ≥97%
  • MDL No. MFCD17215762
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClN₂O
  • Molecular Weight 180.59
  • Synonym(s) 7-Chloro-1,8-naphthyridin-2-ol
  • SMILES C1=CC(=NC2=C1C=CC(=N2)O)Cl

Description

7-Chloro-1H-1,8-naphthyridin-2-one is a bench-stable heterocyclic compound featuring a chlorinated naphthyridinone core. This electron-deficient scaffold integrates readily into medicinal chemistry libraries, serving as a key building block for kinase inhibitors and other bioactive molecules. The para-chloro substitution enhances metabolic stability and modulates electronic properties for targeted molecular interactions.

Application

7-Chloro-1H-1,8-naphthyridin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its electron-deficient naphthyridine core facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions. The chloro substituent provides a reliable handle for further functionalization, while the ketone group supports enolization and subsequent derivatization. This scaffold exhibits excellent bench stability and compatibility with standard synthetic protocols, making it a practical choice for drug discovery campaigns targeting kinase inhibitors and other therapeutic agents.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   1.9888
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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