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CS-W001157 4
Total: USD 88.00

4-Aminobutanenitrile hydrochloride

  • CAS No. 16011-90-8

  • Cat. No. CS-0343605
  • Molecule weight120.58
  • Purity≥97%
  • MDL No.MFCD16619402

*For research and further manufacturing use only, not for direct human use.

4-Aminobutanenitrile hydrochloride|CS-0343605

Structure of 16011-90-8

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General Information

  • CAS No. 16011-90-8
  • Cat. No. CS-0343605
  • Purity ≥97%
  • MDL No. MFCD16619402
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉ClN₂
  • Molecular Weight 120.58
  • Synonym(s) None
  • SMILES N#CCCCN.Cl

Description

4-Aminobutanenitrile hydrochloride is a bench-stable, moisture-tolerant building block featuring a terminal nitrile group and a primary amine functionality. This dual-functionalized intermediate enables efficient coupling in synthetic routes to bioactive molecules, particularly in the development of pharmaceuticals and functional materials requiring polar, reactive handles.

Application

4-Aminobutanenitrile hydrochloride serves as a versatile building block in synthetic organic chemistry, enabling efficient access to γ-aminobutyric acid (GABA) derivatives and nitrogen-containing heterocycles. Its dual functionality—amine and nitrile—facilitates sequential transformations including reduction, cyclization, and nucleophilic addition. The hydrochloride salt enhances bench stability and simplifies handling, while maintaining compatibility with standard coupling and protection protocols.

Synthesis

  • Route1
    • null|null
      110-61-2
    • ~60%
    • In-stock
      Pyrrolidine Hydrochloride|CS-0162629
      25150-61-2
    • In-stock
      4-Aminobutanenitrile hydrochloride|CS-0343605
      16011-90-8

    References

    • Laval, Stephane; Dayoub, Wissam; Pehlivan, Leyla; Metay, Estelle; Favre-Reguillon, Alain; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc Tetrahedron, 2014 , vol. 70, # 4 p. 975 - 983
  • Route2

    References

    • Gardes-Gariglio, Helene; Pornet, Jacques Journal of Organometallic Chemistry, 2001 , vol. 620, # 1-2 p. 94 - 105
  • Route3
    • null|null
      146952-04-7
    • ~92%
    • In-stock
      4-Aminobutanenitrile hydrochloride|CS-0343605
      16011-90-8

    References

    • Haeusler, Johannes Liebigs Annalen der Chemie, 1992 , # 12 p. 1231 - 1238

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.81
  • LogP   0.67068
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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