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Structure of 160542-02-9
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1-Ethynyl-4-(trifluoromethoxy)benzene features a terminal alkyne paired with a strongly electron-withdrawing trifluoromethoxy group, enabling efficient copper-catalyzed coupling reactions. The molecule exhibits excellent stability under standard conditions and delivers high functional group tolerance in synthetic workflows.
1-Ethynyl-4-(trifluoromethoxy)benzene serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated enynes and arylated scaffolds. The terminal alkyne functionality facilitates Sonogashira, Glaser, and related couplings with high chemoselectivity. The trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, making this compound valuable for medicinal chemistry and materials science applications requiring robust functional group tolerance and bench-stable reactivity.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: