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Structure of 16064-25-8
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7-Hydroxyquinazolin-4(3H)-one is a heterocyclic scaffold featuring a hydroxyl group at the 7-position and a lactam functionality at the 4-position, conferring enhanced solubility and hydrogen-bonding capacity. This structural motif serves as a key pharmacophore in kinase inhibitor design, where its planar architecture facilitates target binding. The compound exhibits bench-stable handling characteristics and integrates readily into medicinal chemistry campaigns targeting ATP-binding domains.
7-Hydroxyquinazolin-4(3H)-one serves as a versatile scaffold in medicinal chemistry, enabling direct derivatization at the C7 hydroxyl group via esterification, etherification, or metal-catalyzed coupling. Its bench-stable nature and compatibility with standard protecting group strategies facilitate efficient access to functionalized quinazoline libraries. The core structure supports diverse biological evaluations, particularly in kinase inhibitor development, due to its favorable hydrogen-bonding capacity and planar geometry.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: