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CS-W001157 4
Total: USD 88.00

Bropirimine

  • CAS No. 56741-95-8

  • Cat. No. CS-W009350
  • Molecule weight266.10
  • Purity≥98%
  • MDL No.MFCD00813905

*For research and further manufacturing use only, not for direct human use.

Bropirimine|CS-W009350

Structure of 56741-95-8

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General Information

  • CAS No. 56741-95-8
  • Cat. No. CS-W009350
  • Purity ≥98%
  • MDL No. MFCD00813905
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈BrN₃O
  • Molecular Weight 266.10
  • Synonym(s) U-54461; U-54461S; PNU-54461
  • SMILES O=C1NC(N)=NC(C2=CC=CC=C2)=C1Br

Description

Inducing lymphokine release through immune cell modulation, Bropirimine (CAS 56741-95-8) alters T-cell signaling cascades in immunological assays.

Application

Bropirimine (CAS 56741-95-8) drives interferon cell signaling research by acting as a potent TLR7 agonist, offering a distinct profile compared to imiquimod and R-848. It enhances innate immune activation. Researchers use it to model autoimmune responses in experimental autoimmune encephalomyelitis and explore antitumor effects in bladder cancer systems.

Synthesis

  • Route1

    References

    • Evenaes, Johan; Edfeldt, Fredrik; Lepistoe, Matti; Svitacheva, Naila; Synnergren, Anna; Lundquist, Britta; Graense, Mia; Roennholm, Anna; Varga, Mikael; Wright, John; Wei, Min; Yue, Sherrie; Wang, Junfeng; Li, Chong; Li, Xuan; Chen, Gang; Liao, Yong; Lv, Gang; Tjoernebo, Ann; Narjes, Frank Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 5 p. 1315 - 1321
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    References

    • Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1864 - 1869
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    • In-stock
      Bropirimine|CS-W009350
      56741-95-8

    References

    • Journal of Medicinal Chemistry, , vol. 23, # 3 p. 237 - 239

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H361
Precautionary Statements : P280-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   71.77
  • LogP   1.7816
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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