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Structure of 16097-64-6
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2,4-Dichloro-6-(trifluoromethyl)pyrimidine features a strongly electron-deficient pyrimidine core stabilized by the trifluoromethyl group, enabling selective nucleophilic substitution under mild conditions. This reactivity profile supports efficient coupling in pharmaceutical intermediates and agrochemical synthesis, particularly where halogen-labile sites are required for downstream functionalization.
2,4-Dichloro-6-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling nucleophilic substitution reactions at the C2 and C4 positions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the dichloro substituents provide high reactivity for constructing complex heterocyclic scaffolds. The compound exhibits excellent bench stability and facilitates efficient functionalization under standard coupling conditions, making it well-suited for API development and process-scale synthesis.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: