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Structure of 5993-98-6
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4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine is a trifluoromethyl-substituted pyrimidine featuring a chlorine at C4 and a methyl group at C2, delivering enhanced electron-withdrawing character. This scaffold enables efficient coupling in cross-coupling reactions and serves as a key building block for pharmaceutical intermediates. The trifluoromethyl moiety imparts metabolic stability and improved membrane permeability.
4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloropyrimidine core offers predictable reactivity with nucleophiles, facilitating rapid diversification. The compound exhibits excellent bench stability and compatibility with standard purification protocols, making it well-suited for high-throughput synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: