(4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid

Name: (4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1628684-10-5
Cat. No. CS-0177284
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid|CS-0177284

Structure of 1628684-10-5

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Description

This boronic acid features a chloro-fluoro-methoxy substitution pattern on the phenyl ring, delivering enhanced stability and compatibility in Suzuki-Miyaura cross-coupling reactions. The electron-deficient aryl moiety facilitates efficient coupling under standard conditions, while the methoxy group improves solubility and modulates reactivity.

Application

(4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. Its fluorinated and methoxy-substituted aryl framework provides enhanced metabolic stability and modulates electronic properties, making it valuable for medicinal chemistry and agrochemical synthesis. The boronic acid moiety offers good bench stability, mild reaction conditions, and compatibility with diverse functional groups, facilitating straightforward purification and scalability in synthetic workflows.

General Information

CAS No. 1628684-10-5
Cat. No. CS-0177284
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇BClFO₃
Molecular Weight 204.39
Synonym(s) None
SMILES COC1=C(B(O)O)C(F)=CC(Cl)=C1

Computational Chemistry Data

TPSA 49.69
LogP 0.1675
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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(4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid

CAS No. 1628684-10-5

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