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CS-W001157 4
Total: USD 88.00

1,1-Difluoro-5-azaspiro[2.3]hexane hydrochloride

  • CAS No. 1630906-91-0

  • Cat. No. CS-0052766
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,1-Difluoro-5-azaspiro[2.3]hexane hydrochloride|CS-0052766

Structure of 1630906-91-0

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General Information

  • CAS No. 1630906-91-0
  • Cat. No. CS-0052766
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈ClF₂N
  • Molecular Weight 155.57
  • Synonym(s) None
  • SMILES Cl.FC1(F)CC11CNC1

Description

This difluorinated spirocyclic amine, featuring a constrained five-membered ring with nitrogen and two fluorine atoms, delivers enhanced metabolic stability and improved membrane permeability. The hydrochloride salt form ensures high solubility and crystalline purity, enabling straightforward handling in medicinal chemistry workflows.

Application

1,1-Difluoro-5-azaspiro[2.3]hexane hydrochloride serves as a conformationally constrained difluoromethylated azaspiro scaffold, enabling access to fluorinated bioactive molecules through standard amine functionalization and coupling reactions. Its bench-stable hydrochloride salt facilitates handling and purification, while the spirocyclic framework provides defined stereochemistry and enhanced metabolic stability in medicinal chemistry applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.0368
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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