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Structure of 16357-68-9
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4-Chloropyrimidine-5-carbonitrile features a dual functional handle: a chloro group at C4 and a nitrile at C5, enabling selective cross-coupling and nucleophilic substitution reactions. This electron-deficient pyrimidine scaffold integrates readily into pharmaceutical intermediates and advanced materials, offering high reactivity under mild conditions with excellent bench stability.
4-Chloropyrimidine-5-carbonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its dual functionalization sites—electrophilic chlorine and reactive nitrile—facilitate diverse coupling reactions, including nucleophilic substitution and cyclization protocols. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for modular synthesis workflows targeting heterocyclic APIs and kinase inhibitors.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301+H311+H331
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: