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Structure of 164520-99-4
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4-(Cyclopropylmethoxy)benzaldehyde features a cyclopropylmethyl ether group attached to the para position of a benzaldehyde scaffold, delivering enhanced lipophilicity and metabolic stability. This structural motif enables efficient incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting CNS-penetrant molecules. The aldehyde functionality supports direct derivatization via nucleophilic addition or reductive amination, facilitating rapid library generation under standard conditions.
4-(Cyclopropylmethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its aldehyde functionality facilitates efficient reductive amination, Grignard additions, and Wittig olefination reactions. The cyclopropylmethoxy group provides favorable lipophilicity and metabolic stability, enhancing its utility in lead optimization campaigns. The compound exhibits excellent bench stability and is readily purified by flash chromatography or distillation.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: