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CS-W001157 4
Total: USD 88.00

4-(Cyclopropylmethoxy)benzaldehyde

  • CAS No. 164520-99-4

  • Cat. No. CS-0236990
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

4-(Cyclopropylmethoxy)benzaldehyde|CS-0236990

Structure of 164520-99-4

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Description

4-(Cyclopropylmethoxy)benzaldehyde features a cyclopropylmethyl ether group attached to the para position of a benzaldehyde scaffold, delivering enhanced lipophilicity and metabolic stability. This structural motif enables efficient incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting CNS-penetrant molecules. The aldehyde functionality supports direct derivatization via nucleophilic addition or reductive amination, facilitating rapid library generation under standard conditions.

Application

4-(Cyclopropylmethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its aldehyde functionality facilitates efficient reductive amination, Grignard additions, and Wittig olefination reactions. The cyclopropylmethoxy group provides favorable lipophilicity and metabolic stability, enhancing its utility in lead optimization campaigns. The compound exhibits excellent bench stability and is readily purified by flash chromatography or distillation.

General Information

  • CAS No. 164520-99-4
  • Cat. No. CS-0236990
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O₂
  • Molecular Weight 176.21
  • Synonym(s) 4-(Cyclopropylmethoxy)benzaldehyde b
  • SMILES C1CC1COC2=CC=C(C=C2)C=O

Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.2879
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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