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Structure of 16499-62-0
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4-Chloro-7-fluoroquinazoline delivers a highly reactive scaffold for medicinal chemistry, combining electron-deficient aromaticity with orthogonal functional handles. This bench-stable heterocycle enables direct coupling and cyclization strategies in kinase inhibitor development, where halogen substitution enhances binding affinity and metabolic stability.
4-Chloro-7-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 4- and 7-positions via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its orthogonal reactivity profile supports the construction of diverse quinazoline-based scaffolds with high regiocontrol. The molecule exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in standard synthetic workflows for API development and target-oriented synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: