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CS-W001157 4
Total: USD 88.00

4-Chloro-7-fluoroquinazoline

  • CAS No. 16499-62-0

  • Cat. No. CS-D0286
  • Purity≥96%
  • MDL No.MFCD08236729
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-7-fluoroquinazoline|CS-D0286

Structure of 16499-62-0

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Description

4-Chloro-7-fluoroquinazoline delivers a highly reactive scaffold for medicinal chemistry, combining electron-deficient aromaticity with orthogonal functional handles. This bench-stable heterocycle enables direct coupling and cyclization strategies in kinase inhibitor development, where halogen substitution enhances binding affinity and metabolic stability.

Application

4-Chloro-7-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 4- and 7-positions via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its orthogonal reactivity profile supports the construction of diverse quinazoline-based scaffolds with high regiocontrol. The molecule exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in standard synthetic workflows for API development and target-oriented synthesis.

General Information

  • CAS No. 16499-62-0
  • Cat. No. CS-D0286
  • Purity ≥96%
  • MDL No. MFCD08236729
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄ClFN₂
  • Molecular Weight 182.58
  • Synonym(s) 4-CHLORO-7-FLUORO-QUINAZOLINE
  • SMILES FC1=CC2=NC=NC(Cl)=C2C=C1

Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.4223
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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