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Structure of 2148-57-4
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4,7-Dichloroquinazoline delivers a highly electron-deficient heterocyclic scaffold ideal for transition metal-catalyzed coupling reactions. This bench-stable compound features two strategically positioned chlorine atoms enabling efficient functionalization at C4 and C7 positions. Its rigidity and polar character enhance binding affinity in kinase inhibitor design and support incorporation into advanced pharmaceutical intermediates.
4,7-Dichloroquinazoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at C4 and C7 positions via palladium-catalyzed cross-coupling reactions. Its dual electrophilic sites facilitate the construction of complex quinazoline-based scaffolds with high regiocontrol. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, making it well-suited for iterative synthesis and scale-up in API development.
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GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H318
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Precautionary Statements : P264-P270-P280-P405-P501
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Lot numbers can be found on the outside label of a product: