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CS-W001157 4
Total: USD 88.00

4,7-Dichloroquinazoline

  • CAS No. 2148-57-4

  • Cat. No. CS-W008281
  • Purity≥95%
  • MDL No.MFCD00023911
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4,7-Dichloroquinazoline|CS-W008281

Structure of 2148-57-4

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Description

4,7-Dichloroquinazoline delivers a highly electron-deficient heterocyclic scaffold ideal for transition metal-catalyzed coupling reactions. This bench-stable compound features two strategically positioned chlorine atoms enabling efficient functionalization at C4 and C7 positions. Its rigidity and polar character enhance binding affinity in kinase inhibitor design and support incorporation into advanced pharmaceutical intermediates.

Application

4,7-Dichloroquinazoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at C4 and C7 positions via palladium-catalyzed cross-coupling reactions. Its dual electrophilic sites facilitate the construction of complex quinazoline-based scaffolds with high regiocontrol. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, making it well-suited for iterative synthesis and scale-up in API development.

General Information

  • CAS No. 2148-57-4
  • Cat. No. CS-W008281
  • Purity ≥95%
  • MDL No. MFCD00023911
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄Cl₂N₂
  • Molecular Weight 199.04
  • Synonym(s) 7-dichloroquinazoline
  • SMILES ClC1=CC2=NC=NC(Cl)=C2C=C1

Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.9366
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H318
Precautionary Statements : P264-P270-P280-P405-P501

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