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Cbz-NH-PEG2-CH2COOH

  • CAS No. 165454-06-8

  • Cat. No. CS-0116291
  • Molecule weight297.30
  • Purity≥95%
  • MDL No.MFCD23379879

*For research and further manufacturing use only, not for direct human use.

Cbz-NH-PEG2-CH2COOH|CS-0116291

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General Information

  • CAS No. 165454-06-8
  • Cat. No. CS-0116291
  • Purity ≥95%
  • MDL No. MFCD23379879
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₉NO₆
  • Molecular Weight 297.30
  • Synonym(s) None
  • SMILES O=C(O)COCCOCCNC(OCC1=CC=CC=C1)=O

Description

Cbz-NH-PEG2-CH2COOH features a carbobenzoxy-protected amine linked to a short ethylene glycol chain, terminating in a carboxylic acid. This bifunctional scaffold enables site-specific conjugation in peptide synthesis and bioconjugation workflows. The PEG2 spacer enhances solubility and reduces aggregation, while the Cbz group provides stable protection under standard coupling conditions.

Application

Cbz-NH-PEG2-CH₂COOH serves as a versatile bifunctional linker for peptide and biomolecule conjugation, combining the stability of a Cbz (carbobenzyloxy) amine protecting group with the solubility and flexibility of a short PEG2 spacer. The terminal carboxylic acid enables efficient coupling via standard amide bond formation, while the PEG2 moiety enhances aqueous solubility and reduces aggregation in biological applications. This reagent facilitates clean, high-yield conjugations under routine reaction conditions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   94.09
  • LogP   1.0306
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   10

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