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CS-W001157 4
Total: USD 88.00

2-Isocyanato-1-methoxy-4-(trifluoromethyl)benzene

  • CAS No. 16588-75-3

  • Cat. No. CS-M2408
  • Purity≥98%
  • MDL No.MFCD07644613
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Isocyanato-1-methoxy-4-(trifluoromethyl)benzene|CS-M2408

Structure of 16588-75-3

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Description

2-Isocyanato-1-methoxy-4-(trifluoromethyl)benzene features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the methoxy substituent improves solubility. The isocyanato functionality enables efficient coupling in polymer synthesis and bioconjugation workflows under mild conditions.

Application

2-Isocyanato-1-methoxy-4-(trifluoromethyl)benzene serves as a versatile building block for isocyanate-functionalized aromatic scaffolds, enabling efficient incorporation into ureas, carbamates, and polyurethanes. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the methoxy substituent provides moderate electronic modulation. Its bench-stable isocyanate functionality facilitates straightforward coupling with alcohols and amines under mild conditions, offering reliable access to functionalized intermediates in medicinal chemistry and materials science applications.

General Information

  • CAS No. 16588-75-3
  • Cat. No. CS-M2408
  • Purity ≥98%
  • MDL No. MFCD07644613
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆F₃NO₂
  • Molecular Weight 217.14
  • Synonym(s) 2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE
  • SMILES COC1=CC=C(C(F)(F)F)C=C1N=C=O

Computational Chemistry Data

  • TPSA   38.66
  • LogP   2.6813
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06,GHS08
Signal Word : Danger
UN#: 2928
Class : 6.1,8
Packing Group : Ⅱ
Hazard Statements : H302-H311-H314-H317-H330-H334
Precautionary Statements : P260-P261-P264-P270-P271-P272-P280-P284-P301+P330+P331-P302+P352-P304+P340-P330-P361+P364-P362+P364-P363-P405-P501

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