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Methyl (S)-2-aminopent-4-ynoate hydrochloride

  • CAS No. 166271-28-9

  • Cat. No. CS-0180948
  • Molecule weight163.60
  • Purity≥95%
  • MDL No.MFCD00238137

*For research and further manufacturing use only, not for direct human use.

Methyl (S)-2-aminopent-4-ynoate hydrochloride|CS-0180948

Structure of 166271-28-9

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General Information

  • CAS No. 166271-28-9
  • Cat. No. CS-0180948
  • Purity ≥95%
  • MDL No. MFCD00238137
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀ClNO₂
  • Molecular Weight 163.60
  • Synonym(s) (S)-Methyl 2-aminopent-4-ynoate hydrochloride
  • SMILES C#CC[C@H](N)C(OC)=O.[H]Cl

Description

Methyl 2-aminopent-4-ynoate hydrochloride features a terminal alkyne and primary amine group, enabling direct incorporation into click chemistry and multicomponent reactions. The hydrochloride salt enhances solubility and stability in aqueous media, facilitating use in peptide coupling and bioconjugation workflows under standard conditions.

Application

Methyl 2-aminopent-4-ynoate hydrochloride serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles and conjugated systems. Its terminal alkyne and amine functionalities support diverse transformations including copper-catalyzed azide-alkyne cycloadditions, nucleophilic additions, and transition-metal-mediated coupling reactions. The hydrochloride salt enhances bench stability and facilitates purification, making it well-suited for scalable synthesis and medicinal chemistry applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   -0.0682
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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