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Structure of 167548-89-2
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This trifluoromethyl-substituted thiazole carboxylic acid features a strongly electron-deficient heterocyclic core, enabling efficient coupling in cross-coupling and bioconjugation workflows. The para-positioned trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the carboxylic acid moiety provides a versatile handle for amide formation and derivatization under standard conditions.
4-(Trifluoromethyl)thiazole-5-carboxylic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates direct derivatization or amide formation. The molecule exhibits good bench stability and compatibility with common reaction conditions, making it well-suited for iterative synthetic campaigns targeting drug-like scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: