2-Hydroxy-4-iodobenzoic acid

Name: 2-Hydroxy-4-iodobenzoic acid
Brand: ChemScene
Availability: InStock
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CAS No. 16870-28-3
Cat. No. CS-0103689
Purity≥98%
MDL No.MFCD00061127

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 16870-28-3

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Description

2-Hydroxy-4-iodobenzoic acid features a hydroxyl group ortho to the carboxylic acid and an iodine substituent at the para position, enabling selective functionalization in cross-coupling reactions. The electron-withdrawing iodide enhances reactivity while the adjacent hydroxyl supports hydrogen bonding and solubility in polar solvents. This combination delivers robust performance in synthetic intermediates for pharmaceuticals and advanced materials.

Application

2-Hydroxy-4-iodobenzoic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to biaryl and heteroaryl architectures. The ortho-hydroxyl group provides enhanced solubility and facilitates directed metalation, while the iodide acts as a reliable coupling handle under standard Suzuki, Stille, or Negishi conditions. Bench-stable and readily purified by recrystallization, it functions effectively in late-stage functionalization workflows and synthetic routes to pharmaceutical intermediates.

General Information

CAS No. 16870-28-3
Cat. No. CS-0103689
Purity ≥98%
MDL No. MFCD00061127
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅IO₃
Molecular Weight 264.02
Synonym(s) 4-iodosalicylic acid
SMILES O=C(O)C1=CC=C(I)C=C1O

Computational Chemistry Data

TPSA 57.53
LogP 1.695
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H318-H412
Precautionary Statements : P264-P270-P273-P280-P330-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Phenol

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Hydroxy-4-iodobenzoic acid

CAS No. 16870-28-3

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