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Structure of 16889-72-8
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Tert-butyl isobutyrate is a sterically hindered ester featuring a branched tert-butyl group and a compact isobutyl moiety. This combination imparts enhanced hydrolytic stability and reduced reactivity compared to linear analogs, making it well-suited for use in controlled release systems and as a solvent in sensitive synthetic transformations.
Tert-butyl isobutyrate serves as a stable, bench-ready ester protecting group for carboxylic acids, offering high functional group tolerance and facile removal under mild acidic conditions. Its steric bulk minimizes side reactions during multi-step synthesis, while the tert-butyl moiety enables efficient purification via standard chromatographic methods. This reagent facilitates reliable deprotection in late-stage intermediates and is widely employed in the construction of complex molecular architectures, including pharmaceutical scaffolds and natural product analogs.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 3272
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Class : 3
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Packing Group : Ⅱ
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Hazard Statements : H225-H315-H319
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P362+P364-P370+P378-P501
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Lot numbers can be found on the outside label of a product: