Fmoc-PNA-T-OH

Name: Fmoc-PNA-T-OH
Brand: ChemScene
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CAS No. 169396-92-3
Cat. No. CS-0515485
Molecule weight506.51
Purity≥96%
MDL No.MFCD01940758

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 169396-92-3

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General Information

CAS No. 169396-92-3
Cat. No. CS-0515485
Purity ≥96%
MDL No. MFCD01940758
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₂₆N₄O₇
Molecular Weight 506.51
Synonym(s) Fmoc-C(Bhoc)-Aeg-OH
SMILES O=C(O)CN(C(CN(C(N1)=O)C=C(C)C1=O)=O)CCNC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Description

Fmoc-C(Bhoc)-Aeg-OH is a specialized amino acid derivative designed for solid-phase peptide synthesis. The Fmoc group enables efficient N-terminal protection, while the Bhoc moiety provides orthogonal deprotection under mild conditions. The Aeg linker offers stable coupling and facilitates purification. This compound integrates seamlessly into complex peptide architectures with high fidelity and minimal side reactions.

Application

Fmoc-C(Bhoc)-Aeg-OH serves as a versatile building block for peptide synthesis, enabling the incorporation of a C-terminal aldehyde-functionalized amino acid derivative. The Fmoc group provides orthogonal protection for the amine, while the Bhoc (benzyloxycarbonyl) moiety offers stable, acid-labile protection for the side-chain hydroxyl. This combination facilitates efficient coupling reactions and selective deprotection, supporting the construction of complex peptide architectures and bioconjugation intermediates with high functional group tolerance and bench stability.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

TPSA 150.8
LogP 1.29692
H_Acceptors 7
H_Donors 3
Rotatable_Bonds 9

Other Classifications

Life Science Amino Acids and their Derivatives Glycine and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Peptide Nucleic Acid (PNA) Monomers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Peptide Nucleic Acid (PNA) Monomers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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Fmoc-PNA-T-OH

CAS No. 169396-92-3

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