Fmoc-PNA-G(Bhoc)-OH

Name: Fmoc-PNA-G(Bhoc)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 186046-83-3
Cat. No. CS-0068937
Purity≥98%
MDL No.MFCD01940756

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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*For research and further manufacturing use only, not for direct human use.

Structure of 186046-83-3

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Description

Fmoc-PNA-G(Bhoc)-OH is a protected nucleobase-functionalized peptide nucleic acid monomer designed for sequence-specific hybridization studies. The Fmoc group enables efficient solid-phase synthesis, while the Bhoc-protected guanine moiety ensures orthogonal deprotection and stability during chain elongation. This derivative facilitates the incorporation of guanine residues into PNA strands with high fidelity and minimal side reactions.

Application

Fmoc-PNA-G(Bhoc)-OH serves as a key building block for solid-phase peptide synthesis, enabling efficient incorporation of guanidino-functionalized amino acids into peptidic scaffolds. The Bhoc-protected guanidine group offers high stability under standard Fmoc deprotection conditions and facilitates selective deprotection during late-stage functionalization. This derivative enables reliable access to biologically relevant sequences with enhanced solubility and hydrogen-bonding capacity.

General Information

CAS No. 186046-83-3
Cat. No. CS-0068937
Purity ≥98%
MDL No. MFCD01940756
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₀H₃₅N₇O₈
Molecular Weight 741.75
Synonym(s) None
SMILES O=C(O)CN(C(CN1C=NC2=C1N=C(NC(OC(C3=CC=CC=C3)C4=CC=CC=C4)=O)NC2=O)=O)CCNC(OCC5C6=C(C7=C5C=CC=C7)C=CC=C6)=O

Computational Chemistry Data

TPSA 197.84
LogP 4.9096
H_Acceptors 10
H_Donors 4
Rotatable_Bonds 13

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Purine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Peptide Nucleic Acid (PNA) Monomers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Peptide Nucleic Acid (PNA) Monomers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

Key Words

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Fmoc-PNA-G(Bhoc)-OH

CAS No. 186046-83-3

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