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Hydroxy-PEG4-CH2-Boc

  • CAS No. 169751-72-8

  • Cat. No. CS-0024772
  • Molecule weight308.37
  • Purity≥97%
  • MDL No.MFCD27635170

*For research and further manufacturing use only, not for direct human use.

Hydroxy-PEG4-CH2-Boc|CS-0024772

Structure of 169751-72-8

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General Information

  • CAS No. 169751-72-8
  • Cat. No. CS-0024772
  • Purity ≥97%
  • MDL No. MFCD27635170
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₈O₇
  • Molecular Weight 308.37
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)COCCOCCOCCOCCO

Description

Hydroxy-PEG4-CH2-Boc features a hydroxyl-terminated PEG4 spacer linked to a Boc-protected amine via a methylene bridge. This bifunctional intermediate enables controlled conjugation and protection in peptide synthesis and bioconjugation workflows. The hydrophilic PEG chain enhances solubility, while the stable Boc group allows for selective deprotection under mild acidic conditions.

Application

Hydroxy-PEG4-CH2-Boc serves as a versatile, bench-stable building block for the synthesis of PEGylated compounds and bioconjugates. The hydroxyl group enables straightforward derivatization, while the Boc-protected amine offers orthogonal functionality for selective coupling. Its PEG4 spacer provides enhanced solubility and reduced aggregation, facilitating purification and downstream applications in medicinal chemistry and polymer science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   83.45
  • LogP   0.3868
  • H_Acceptors   7
  • H_Donors   1
  • Rotatable_Bonds   13

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