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Structure of 1699190-56-1
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4-Chloro-2-cyclopropyl-7-fluoroquinazoline features a fused heterocyclic core with strategically positioned halogen and cyclopropyl substituents, enhancing electron-deficient character and metabolic stability. This scaffold integrates readily into kinase inhibitor libraries, offering improved binding affinity and solubility profiles in medicinal chemistry campaigns.
4-Chloro-2-cyclopropyl-7-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. Its orthogonal functional groups facilitate palladium-catalyzed cross-coupling reactions and nucleophilic substitution, with the cyclopropyl and fluoro substituents enhancing metabolic stability and target binding affinity. The compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthesis and process-scale applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: