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Structure of 1699249-56-3
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4,6,7-Trifluoro-1H-indole-2-carboxylic acid features a trifluorinated indole core with a carboxylic acid group at the 2-position, offering enhanced electron deficiency and metabolic stability. This configuration enables direct incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds. The fluorinated framework improves membrane permeability and resistance to oxidative degradation, facilitating efficient synthesis and downstream derivatization under standard conditions.
4,6,7-Trifluoro-1H-indole-2-carboxylic acid serves as a versatile building block for the synthesis of fluorinated heterocycles and bioactive scaffolds. Its trifluoromethylated indole core enables enhanced metabolic stability and modulated lipophilicity in medicinal chemistry applications. The carboxylic acid functionality facilitates direct coupling reactions and derivatization under standard amide bond formation conditions, offering efficient access to peptide-like conjugates and macrocyclic architectures. The molecule exhibits good bench stability and is compatible with common purification methods.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: