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Structure of 247564-67-6
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4,7-Difluoro-1H-indole-2-carboxylic acid features a fluorinated indole core with electron-withdrawing difluoro substitution at the 4 and 7 positions, enhancing metabolic stability and modulating electronic properties. The carboxylic acid group enables direct conjugation or derivatization in medicinal chemistry campaigns. This scaffold integrates readily into bioactive molecules for kinase inhibition and CNS-targeted drug discovery.
4,7-Difluoro-1H-indole-2-carboxylic acid serves as a valuable building block for the synthesis of fluorinated indole derivatives, enabling direct incorporation of two strategically positioned fluorine atoms to modulate electronic properties and metabolic stability. Its carboxylic acid functionality facilitates straightforward coupling reactions, including amide formation and esterification, while maintaining compatibility with common protecting group strategies. The compound exhibits good bench stability and is well-suited for use in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: