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CS-W001157 4
Total: USD 88.00

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

  • CAS No. 170097-67-3

  • Cat. No. CS-W005911
  • Purity≥98%
  • MDL No.MFCD05861548
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid|CS-W005911

Structure of 170097-67-3

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Description

This tetrahydroisoquinoline derivative features a tert-butoxycarbonyl-protected amine and a carboxylic acid group at the 6-position, enabling direct incorporation into peptide conjugates or heterocyclic scaffolds. The Boc group ensures stability during synthesis, while the electron-rich aromatic core facilitates transition metal-catalyzed coupling reactions under standard conditions.

Application

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid serves as a versatile building block for the synthesis of tetrahydroisoquinoline-based scaffolds. The tert-butoxycarbonyl group provides robust protection of the amine, enabling stable handling and compatibility with diverse coupling reactions. The carboxylic acid functionality facilitates efficient derivatization and conjugation, supporting applications in medicinal chemistry and peptide synthesis. Its structural integrity and functional group orthogonality make it a reliable intermediate in multi-step synthetic sequences.

General Information

  • CAS No. 170097-67-3
  • Cat. No. CS-W005911
  • Purity ≥98%
  • MDL No. MFCD05861548
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₉NO₄
  • Molecular Weight 277.32
  • Synonym(s) N-Boc-6-Hydroxycarbonyl-1,2,3,4-Tetrahydroisoquinoline
  • SMILES CC(C)(C)OC(=O)N1CCC2=CC(=CC=C2C1)C(O)=O

Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.678
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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