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CS-W001157 4
Total: USD 88.00

Benzenemethanol, 4-(dimethylamino)-

  • CAS No. 1703-46-4

  • Cat. No. CS-0030804
  • Purity≥98%
  • MDL No.MFCD03840449

*For research and further manufacturing use only, not for direct human use.

Benzenemethanol, 4-(dimethylamino)-|CS-0030804

Structure of 1703-46-4

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General Information

  • CAS No. 1703-46-4
  • Cat. No. CS-0030804
  • Purity ≥98%
  • MDL No. MFCD03840449
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃NO
  • Molecular Weight 151.21
  • Synonym(s) Benzenemethanol, 4-(dimethylamino)-
  • SMILES CN(C1=CC=C(C=C1)CO)C

Description

4-(Dimethylamino)benzyl alcohol features a para-dimethylamino substituent that enhances electron density and solubility in polar media. The primary alcohol group enables straightforward derivatization, while the aromatic scaffold provides stability under standard reaction conditions. This compound serves as a key building block in pharmaceutical intermediates and fluorescent probe synthesis.

Application

4-(Dimethylamino)benzyl alcohol serves as a versatile building block in medicinal chemistry, enabling the synthesis of diverse heterocyclic scaffolds and bioactive compounds. Its phenolic hydroxyl group facilitates straightforward derivatization, while the electron-rich dimethylaminobenzyl moiety enhances solubility and supports efficient coupling reactions. The compound exhibits excellent bench stability and ease of purification, making it well-suited for iterative synthetic workflows and scale-up applications.

Synthesis

  • Route1

    References

    • SAUDAN, Lionel; Dupau, Philippe; Riedhauser, Jean-Jacques; Wyss, Patrick Patent: US2008/71121 A1, 2008 ; Location in patent: Page/Page column 13 ;
  • Route2

    References

    • Manas, Michael G.; Graeupner, Jonathan; Allen, Laura J.; Dobereiner, Graham E.; Rippy, Kerry C.; Hazari, Nilay; Crabtree, Robert H. Organometallics, 2013 , vol. 32, # 16 p. 4501 - 4506
  • Route3
    • In-stock
      p-Dimethylaminobenzaldehyde|CS-W020083
      100-10-7
    • null|null
      100-46-9
    • ~5%
    • 4-((Benzylamino)methyl)-N,N-dimethylaniline|CS-0300245
      55096-85-0
    • In-stock
      Benzenemethanol, 4-(dimethylamino)-|CS-0030804
      1703-46-4

    References

    • Tetrahedron Letters, , vol. 53, # 25 p. 3156 - 3160

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H227-H301+H311+H331-H373-H412
Precautionary Statements : P210-P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P361+P364-P370+P378-P403-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   1.2449
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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