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Structure of 170621-86-0
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4-Chloro-3-methoxypicolinic acid features a strategically positioned chloro group and methoxy substituent on the picolinic acid scaffold, enhancing electronic modulation and metabolic stability. This electron-deficient heterocycle integrates readily into bioactive scaffolds, serving as a key building block for pharmaceutical intermediates and ligand design under standard conditions.
4-Chloro-3-methoxypicolinic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring via palladium-catalyzed cross-coupling. Its chloro group facilitates Suzuki, Stille, and Negishi reactions, while the methoxy and carboxylic acid functionalities provide orthogonal handles for further derivatization. Bench-stable and readily purified by recrystallization, it functions effectively in the synthesis of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: