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Structure of 395-82-4
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4-Fluoro-2-methoxybenzoic acid features a strategically positioned fluorine atom and methoxy group that enhance electronic effects and metabolic stability. This ortho-substituted benzoic acid derivative integrates readily into pharmaceutical scaffolds, offering improved solubility and targeted reactivity in synthetic transformations.
4-Fluoro-2-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via standard esterification, amide coupling, or Suzuki-Miyaura cross-coupling reactions. Its ortho-methoxy and meta-fluoro substituents provide enhanced metabolic stability and modulate electronic properties for target engagement. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses of pharmaceutical intermediates and functionalized heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: