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Structure of 170886-13-2
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2-(Trifluoromethyl)pyridin-4-ol features a trifluoromethyl group at the ortho position relative to a phenolic hydroxyl, imparting enhanced electron-withdrawing character and improved metabolic stability. The pyridinic nitrogen provides a polar, basic site for coordination or derivatization. This combination enables direct incorporation into bioactive scaffolds and functional materials requiring both solubility and resistance to oxidative degradation under standard conditions.
2-(Trifluoromethyl)pyridin-4-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized heterocycles through direct coupling and electrophilic substitution. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the phenolic hydroxyl offers a reliable handle for derivatization via etherification or esterification. The compound exhibits good bench stability and compatibility with common reaction conditions, facilitating integration into multi-step syntheses of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: