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CS-W001157 4
Total: USD 88.00

1-(Chloromethyl)-1,1,3,3,3-pentamethyldisiloxane

  • CAS No. 17201-83-1

  • Cat. No. CS-0186270
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(Chloromethyl)-1,1,3,3,3-pentamethyldisiloxane|CS-0186270

Structure of 17201-83-1

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Description

This chloromethyl-functionalized disiloxane delivers a highly reactive electrophilic handle for silicon-directed conjugation. The pentamethyl-substituted framework imparts exceptional steric shielding and moisture tolerance, enabling reliable coupling under standard bench conditions.

Application

1-(Chloromethyl)-1,1,3,3,3-pentamethyldisiloxane serves as a robust, bench-stable silyl-protecting group reagent that enables selective functionalization of nucleophiles under mild conditions. Its sterically shielded disiloxane backbone enhances stability and minimizes side reactions, while the chloromethyl group facilitates efficient alkylation and downstream transformations. Ideal for constructing complex architectures in medicinal chemistry and materials science workflows.

General Information

  • CAS No. 17201-83-1
  • Cat. No. CS-0186270
  • Purity ≥97%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₇ClOSi₂
  • Molecular Weight 196.82
  • Synonym(s) Chloromethylpentamethyldisiloxane
  • SMILES C[Si](C)(C)O[Si](C)(C)CCl

Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.821
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group :
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

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