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CS-W001157 4
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3-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoic acid

  • CAS No. 172965-84-3

  • Cat. No. CS-0058660
  • Purity≥95%
  • MDL No.MFCD01861327

*For research and further manufacturing use only, not for direct human use.

3-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoic acid|CS-0058660

Structure of 172965-84-3

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General Information

  • CAS No. 172965-84-3
  • Cat. No. CS-0058660
  • Purity ≥95%
  • MDL No. MFCD01861327
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₉NO₄
  • Molecular Weight 325.36
  • Synonym(s) None
  • SMILES O=C(N(C)CCC(O)=O)OCC1C2=C(C=CC=C2)C3=C1C=CC=C3

Description

This fluorenylmethoxycarbonyl-protected amino acid derivative features a robust C-terminal carbamate linkage, enabling efficient coupling in solid-phase peptide synthesis. The fluoren-9-ylmethoxy carbonyl (Fmoc) group ensures high-yield deprotection under mild basic conditions, while the methylamino side chain provides enhanced solubility and reduced aggregation during chain assembly.

Application

3-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoic acid serves as a versatile protected amino acid building block, enabling efficient peptide synthesis via standard coupling protocols. The Fmoc-methylamino group offers high stability under basic conditions and facilitates rapid deprotection, while the propanoic acid side chain provides a well-defined functional handle for further diversification. Its bench-stable nature and compatibility with common purification methods make it ideal for iterative solid-phase and solution-phase synthesis workflows.

Synthesis

  • Route1
    • null|null
      50-00-0
    • In-stock
      Fmoc-β-Ala-OH|CS-W007942
      35737-10-1
    • ~%
    • In-stock
      3-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoic acid|CS-0058660
      172965-84-3

    References

    • Tetrahedron Letters, , vol. 37, # 2 p. 263 - 266

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   3.342
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   5

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