(R)-2-Amino-2-(4-fluorophenyl)ethan-1-ol

Name: (R)-2-Amino-2-(4-fluorophenyl)ethan-1-ol
Brand: ChemScene
Availability: InStock
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CAS No. 174770-74-2
Cat. No. CS-0037604
Purity≥97%
MDL No.MFCD09253715

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-2-Amino-2-(4-fluorophenyl)ethan-1-ol|CS-0037604

Structure of 174770-74-2

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Description

(R)-2-Amino-2-(4-fluorophenyl)ethan-1-ol is a chiral building block featuring a primary amine and hydroxyl group flanking a stereogenic center. This configuration enables selective incorporation into bioactive molecules, particularly in the synthesis of pharmaceutical intermediates requiring defined stereochemistry. The fluorophenyl moiety enhances metabolic stability and modulates electronic properties, supporting efficient integration into complex scaffolds under standard conditions.

Application

(R)-2-Amino-2-(4-fluorophenyl)ethan-1-ol serves as a key chiral building block for the synthesis of bioactive molecules, particularly in medicinal chemistry. Its well-defined stereochemistry and stable hydroxylamine functionality enable reliable coupling and derivatization. The molecule exhibits good bench stability and facilitates efficient incorporation into heterocyclic scaffolds via standard amine-aldehyde condensation or cyclization protocols.

General Information

CAS No. 174770-74-2
Cat. No. CS-0037604
Purity ≥97%
MDL No. MFCD09253715
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₀FNO
Molecular Weight 155.17
Synonym(s) Benzeneethanol, beta-amino-4-fluoro-, (betaR)-
SMILES C1=C(C=CC(=C1)F)[C@H](CO)N

Computational Chemistry Data

TPSA 46.25
LogP 0.8178
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-2-Amino-2-(4-fluorophenyl)ethan-1-ol

CAS No. 174770-74-2

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