4-(3,4-Difluorophenyl)thiazol-2-amine

Name: 4-(3,4-Difluorophenyl)thiazol-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 175135-32-7
Cat. No. CS-0157111
Purity≥98%
MDL No.MFCD00052876

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-(3,4-Difluorophenyl)thiazol-2-amine|CS-0157111

Structure of 175135-32-7

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Description

4-(3,4-Difluorophenyl)thiazol-2-amine features a fluorinated aryl moiety that enhances metabolic stability and membrane permeability. The thiazole scaffold provides a rigid, electron-deficient platform ideal for hydrogen bonding and π–stacking interactions in target binding. This compound serves as a key building block in kinase inhibitor and medicinal chemistry libraries, offering improved solubility and synthetic versatility under standard conditions.

Application

4-(3,4-Difluorophenyl)thiazol-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling and electrophilic substitution reactions. The thiazole core exhibits robust bench stability and tolerates a range of functional groups, facilitating efficient synthesis of pharmaceutical intermediates and kinase inhibitor scaffolds. Its dual aromatic systems support π–π interactions in target binding, enhancing molecular recognition potential.

General Information

CAS No. 175135-32-7
Cat. No. CS-0157111
Purity ≥98%
MDL No. MFCD00052876
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₆F₂N₂S
Molecular Weight 212.22
Synonym(s) 4-(3,4-Difluorophenyl)-1,3-thiazol-2-amine
SMILES NC1=NC(C2=CC=C(F)C(F)=C2)=CS1

Computational Chemistry Data

TPSA 38.91
LogP 2.6705
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-(3,4-Difluorophenyl)thiazol-2-amine

CAS No. 175135-32-7

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