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CS-W001157 4
Total: USD 88.00

6-(Trifluoromethoxy)quinolin-4-ol

  • CAS No. 175203-87-9

  • Cat. No. CS-0080607
  • Purity≥98%
  • MDL No.MFCD00219858

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethoxy)quinolin-4-ol|CS-0080607

Structure of 175203-87-9

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General Information

  • CAS No. 175203-87-9
  • Cat. No. CS-0080607
  • Purity ≥98%
  • MDL No. MFCD00219858
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆F₃NO₂
  • Molecular Weight 229.16
  • Synonym(s) BUTTPARK 10\01-39
  • SMILES FC(F)(F)OC1=CC(C(O)=CC=N2)=C2C=C1

Description

6-(Trifluoromethoxy)quinolin-4-ol integrates a trifluoromethoxy group at the 6-position and a hydroxyl moiety at the 4-position of the quinoline scaffold. This configuration imparts enhanced electron-withdrawing character and improved solubility in polar solvents, enabling efficient incorporation into bioactive scaffolds for medicinal chemistry campaigns.

Application

6-(Trifluoromethoxy)quinolin-4-ol serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via standard coupling reactions. Its trifluoromethoxy group enhances metabolic stability and lipophilicity, while the phenolic hydroxyl facilitates derivatization or metal-catalyzed cross-coupling. Bench-stable and compatible with common purification methods, it functions effectively in the synthesis of quinoline-based pharmaceuticals and functional materials.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   42.35
  • LogP   2.839
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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