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CS-W001157 4
Total: USD 88.00

4-Chloro-2-(trifluoromethoxy)aniline

  • CAS No. 175205-77-3

  • Cat. No. CS-W015037
  • Purity≥95%
  • MDL No.MFCD00153102

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-(trifluoromethoxy)aniline|CS-W015037

Structure of 175205-77-3

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General Information

  • CAS No. 175205-77-3
  • Cat. No. CS-W015037
  • Purity ≥95%
  • MDL No. MFCD00153102
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClF₃NO
  • Molecular Weight 211.57
  • Synonym(s) 4-CHLORO-2-(TRIFLUOROMETHXY)ANILINE
  • SMILES NC1=CC=C(Cl)C=C1OC(F)(F)F

Description

4-Chloro-2-(trifluoromethoxy)aniline features a trifluoromethoxy group that enhances electron-withdrawal and metabolic stability, while the ortho-chloro substituent provides steric and electronic modulation. This aniline derivative serves as a key building block in pharmaceutical intermediates and agrochemicals, offering improved solubility and reactivity under standard conditions.

Application

4-Chloro-2-(trifluoromethoxy)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via standard coupling reactions. Its trifluoromethoxy group enhances metabolic stability and lipophilicity, while the chloro substituent facilitates palladium-catalyzed cross-coupling transformations. The compound exhibits good bench stability and is compatible with common protecting group strategies, supporting streamlined synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.8208
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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